Fase I studies

Servier CL-98012-002

4 november 2022
An open label, multicentre, positron emission tomography (PET) imaging study using Zirconium-89 to investigate the biodistribution and tumor uptake of a PD-L1x4-1BB bispecific antibody (SO95012) in patients with...

INCB81776-101

10 oktober 2022
A Phase 1a/1b Study exploring the safety and tolerability of INCB081776 +/- retifanlimab in participants with advanced malignancies Protocol: INCB 81776-101 EudraCT Number: 2020-004867-26 Een Fase 1a/1b, open label...

LAG-3

7 januari 2022
ImmunoPET imaging with 89Zr-DFO-REGN3767 in patients with advanced solid cancer prior to and during treatment with cemipliamb with or without platinum-based chemotherapy. Samenvatting 89Zr-DFO-REGN3767 is een experimentele PET...

Potentia

3 september 2021
A Phase 1 Open-Label, Dose Escalation and Expansion Trial to Investigate the Safety, harmacokinetics and Pharmacodynamics of CB307, a Trispecific Humabody® T-cell Enhancer, in Patients with PSMA+ Advanced...

Dragonfly

30 augustus 2021
A Phase I/II, First-In-Human, Multi-Part, Open-Label, Multiple Ascending Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, Biological, and Clinical Activity of DF1001 in Patients With Locally Advanced or...

GO41596

3 juni 2021
A phase Ia/Ib, open-label, multicenter, global, dose-escalation study to evaluate the safety and pharmacokinetics of XmAb24306 as a single agent and in combination with atezolizumab in patients with...

PD-L1 treatment

12 april 2021

DEBIO-0123

A phase 1 study of oral Debio 0123 in combination with carboplatin in patients with advanced solid tumors. Protocolnummer: Debio 0123-101 EudraCT nummer: 2018-003659-39 METc nummer: 2019/631 Samenvatting...

M15-913

An Open Label Phase 1, First-In-Human Study of TRAIL Receptor Agonist ABBV-621 in Subjects with Previously-Treated Solid Tumors and Hematologic Malignancies. M15-913 Protocolnummer: M15-913 Eudract nummer: 2016-003887-37 METc...

CD8 PET imaging studie (GENENTECH)

Een fase 1-2 immunoPET imaging studie met ZED88082A/CED88004S in patiënten voor en tijdens behandeling met 1) MPDL3280A of 2) PD-1 antilichaam met of zonder ipilimumab. Protocolnummer: Eudract nummer:...